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Thread: Delta F508 & G542X

  1. #1

    Delta F508 & G542X

    Anyone have this combination that is supposed to be a rare one?

  2. #2
    Digital opinion leader
    Join Date
    Sep 2016
    Posts
    6
    My boys do. I thought it was one of the more common ones.

  3. #3
    Only somewhere around 3% according to a Facebook post from the CF site

  4. #4
    Junior Member
    Join Date
    Oct 2010
    Posts
    19
    I guess i fall in that 3% than too , totally feel free to pm if you got any questions.

  5. #5
    Junior Member
    Join Date
    Jan 2007
    Posts
    1
    Both my kids do.

  6. #6
    bamagirl22
    Guest
    I have this combo as well.

  7. #7
    We should start our own sub-club!

    Only DF508 and G542X allowed!

    Oh, and by the way, G542X means you're jewish.

  8. #8
    Senior Member
    Join Date
    Jan 2006
    Posts
    134
    I have D508 and G542X and am not Jewish. No Jewish heritage, as far as I know. FYI.

  9. #9
    Junior Member
    Join Date
    May 2009
    Posts
    29
    My daughter who passed away did. After DD508 this is probably the next common combination. Also G542X has been traced to the Ashkenazi Jews.

  10. #10
    Junior Member
    Join Date
    Nov 2014
    Posts
    2
    So sorry for your loss Julie. Our oldest daughter passed away Feb 2013 at 2 years, 4 months old and carried both of these mutations. My second daughter carries DF508 and is fine. I just found out today that my newborn son's (9 days old) newborn screening has come back positive for CF with these mutations. We go in next week to run the sweat test to get the final diagnosis, but I guess we pretty much know already what the result will be.

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