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Thread: My son has this combination: 3849+10kbC and 712-G->T

  1. #1
    Junior Member
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    Jun 2017
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    Unhappy My son has this combination: 3849+10kbC and 712-G->T

    Hello everybodoy!
    My name is Javier, I´m from Spain. Recently, my son has been diagnosed with atypical cystic fibrosis. He is 5 and he is SP.
    His mutations are:
    A) 3849+10kbC>T (C.3717+10KbC>T)
    B)712-G-> T (C.580-1G>t)

    Until now he has had no graves of affections, only coughs. He never hasn´t hospitalized. He was recently detected staphylococci aereus. In the sweat test he gave 52. The general condition is good and the FEV is 100.

    We are very precarious and desperate because nobody gives us much information of the forecast.
    Someone could help us? Do you know something about phenotype resulting? THANK YOU VERY MUCH

    Sorry for my english

  2. #2
    Administrator
    Join Date
    Dec 2007
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    2,213
    Javier,

    Welcome to the CF forums! I'm sorry about your son's diagnosis but glad you found this website and that your son is doing well and with perhaps a milder presentation of the disease.

    As you know, certain mutations impair CFTR function more than others, yet people with the same mutations will often have different severity and even different focus (gastrointestinal vs pulmonary) of CF symptoms. So there are many factors at play in forecast and outcomes.

    You may want to check out this website which is a database of mutations https://www.cftr2.org/

    Also, while this thread about CF genetics is long, especially in another language, you might end up reading it from beginning to end as it is pretty interesting http://forums.cysticfibrosis.com/sho...ighlight=ambry

    By the way, your English is great. Yo soy de los EE.UU., pero hablo español porque mi madre is de Buenos Aires. Sin embargo, de las palabras científicas y de medicina, no sé mucho. Espero que más gente responda a tus preguntas, especialmente padres y familia de niños con CF.
    40 year-old with non-CF bronchiectasis. Writer and editor, and mom of two tweens and a teen. Always grateful for the inspiration members of this site give me to exercise and more.

  3. #3
    Junior Member
    Join Date
    Jun 2017
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    1
    Hola!!

    Soy mexicana con 3849+10kbC>T y F508 Delta y tengo 20 años. Mi familia se mudó a los Estados Unidos porque en Mexico los doctores no sabían que tenía. Me han dicho que la mutación que hijo y yo tenemos es muy rara. Yo no tengo problemas con el pancreas, pero si he desarrollado sinusitis. Parece que tu hijo está saludable. Es muy importante que toda la gente que interactue con el se lave las manos para que no le den infecciones. Si se enferma con Pseudomonas aeruginosa, es bastante difícil de encontrar una medicina que no se vuelva resistente a la bacteria. Mientras no se enferme, traten de que el niño sea activo para que no se le acumule las flemas. Puede escupir? Una prima mia tiene una hija con fibrosis quistica de 5 años y apenas le dieron medicina por el nebulizador.

    Es bastante difícil de comprender y la verdad no es fácil vivir con la enfermedad. Claro, cada experiencia es diferente pero al fin del día abarca mucho tiempo y energía con los tratamientos y sentirse enfermo. Una cosa que hubiera querido cuando yo estaba chica es que la familia hable de la enfermedad y no le ponga un tabu incomodo. Lamentablemente la enfermedad existe, pero con medicina y el apoyo de los doctores y familia es mas facil navegarla.

    Si tienes otras preguntas en español o ingles puedes mandarme un mensaje por aqui!!

    Suerte,
    Daniela

  4. #4
    Hi, my daughter is 10 and has the same first mutation as your son. She is doping well, never was hospitalized. She is strong on sports and oferty much a normal kid going to publicznych school.we are from Poland.

  5. #5
    Senior Member
    Join Date
    Jan 2009
    Posts
    1,296
    My daughter is 10 and has the same first mutation as well. she is pancreatic sufficient and doing relatively well. She had several PA infections though, but hasn't been hospitalized yet. It is difficult to tell who the desease will evolve based on mutations, so i think it is a good thing that no one gives you a prognosis. Just follow your treatment plan and do the best you can, that would be my advice

  6. #6
    Super Moderator
    Join Date
    Dec 2011
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    758
    This is probably the most international meeting of CFers in a while.

    More and more mutations and especially mutation combinations that are being discovered in the people who are suspected of having CF. The standard for CF is still claiming that 2 identical mutations are required to be affected a person. This was when most people suspected of having CF mostly Did have two identical mutations. Now polymorphisms (5T, 7T, 9T and TG's for example) are getting the status of a mutation.

    Still, CF is a rare disease with a world population of of ~70,000, 73% of which share 5 mutation sets. There's around 3000 known CFTR mutations shared with the ~19,000 people. If they were evenly distributed, only six people would share a mutation set. It gets worse, we now know that combinations are virulent in many cases. This is 4.5 million combinations, far more than the highest estimate of the world CF population. My mutation, S1235R has one person in the CFTR2 Database and it's not virulent and it isn't me. Fortunately I was tested using the sweat chloride test and confirmed with CF before any genetic testing.

    After my genetic testing came in I saw my CF specialist. I had met him once before, when the genetic testing was ordered. At the appointment where we discussed the results of my genetic testing, the first words out of his mouth were "so, you're a carrier". Ordinarily, this news would be crushing, after fifty years I have a diagnosis and you are going to take it back? I'm a geneticist and if I know anything about genetics, I know that certainty is very rare.

    The CF diagnosis wasn't on anybody's radar including a host of specialists. Don't be too hard on your doctors, the only reason my diagnosis was at a CF center in Boston and not Denver was because the tiniest bit of calcification had shown in my pancreas. This tiny clue got my wife going and we found one of about 4 Pancreatologists in the U.S. After being given a Pancreatic function test and being told it was a record for bad, I was sent the Boston Children's Hospital for a sweat chloride test.

    I have two points to make. If you or your child shows symptoms of CF, being treated like it's CF is most important. A failed sweat test does not rule out CF, and neither should genetic testing, and treatment is going to be the same with the exception of the current genetic drugs. If it looks like a duck, quacks like a duck and walks like a duck, treat it like a duck. Think about all the people who were diagnosed with CF before 1989 when we decoded the CFTR and identified a few mutations. Some have no CF mutations, some are symptomatic carriers, and the majority are genetically a CFer. Twin studies have established that two CFers, genetically diagnosed, may have wildly different health issues. I spent some time messaging with siblings, actually just the sibling that doesn't have any CF issues. Her younger brother was ravaged by the disease.

    The other point, as much as we would like to hear about the issues caused by our mutations by comparing notes with others who do share them, it's not something you can rely on in most cases. Some general trends can be inferred if you have a mutation set that has maybe a dozen registered people with your mutations and some other mutation or both of your mutations if you are lucky. The whole reason for the CFTR and CFTR2 Databases is a resource for inputting your mutations and see what other people who have registered experience as a trend. Google CFTR2 Database and it will take you there.

    Just remember, CF has an extreme range of symptoms with genetically CF patients being denied a diagnosis because they aren't sick to carriers that require a transplant. Chances are that he would be much worse if his CF was going to be severe. There could be a development of respiratory issues with time but it too is wildly variable.

    Keep up with CFTR2 and over time it will become reliable as numbers increase.

    LL
    67yr. old man, DX CF 2002 by sweat test. Heterozygous S1235R revealed by genetic testing in 2003 & 2012 accepted secondary mutation. 7T, 7T polymorphism established to be virulent. Classification review in 2017 remains CF diagnosis.

    Complete pancreatic atrophy, Bronchiectasis, MRSA, osteoporosis, small duct disease, charming personality.

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