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Jem
06-11-2007, 06:38 PM
<b>I received this...not sure of the validity but it is worth looking into if you are using pre-mixed vials of Colistin.</b>

Date: 6/11/2007 8:09 AM

Subject: URGENT: Colistin Alert from the Office of Drs. Preston Campbell and Bruce Marshall

Attachments: Attachment A, Colistin MedWatch 053107.pdf; Attachment B, Antimicrobia Journal Stability of Colistin Apr 2003.pdf; Attachment C, Poster 8 Day
Inhalation Toxicology of Polymyxin E1 in Colistin June 2001.pdf


TO: All Cystic Fibrosis Foundation Care Centers


FROM: Preston W. Campbell, III, M.D.

Executive Vice President for Medical Affairs

and

Bruce C. Marshall, M.D., Vice President for

Clinical Affairs

and

Leslie Hazle, M.S., C.P.N., R.N., Director of

Patient Resources


RE: Colistin Alert


We wanted to let you know that the Food and Drug Administration (FDA) is

investigating a recent patient death as possibly being related to

inhaled colistin that was supplied by a compounding pharmacy in premixed

unit dose vials. The purpose of this memo is to inform the prescribing

community of this unfortunate death (Attachment A) and give you

additional details regarding the hydrolysis of the prodrug

colistimethate to more toxic compounds when stored in solution. Our

recommendation is that patients not use premixed unit dose vials of

Colistimethate until the FDA investigation is complete and the safety of

this product is established.


The patient was a 29-year-old woman with cystic fibrosis (CF) with

chronic airway Pseudomonas aeruginosa infection with moderate lung

disease, clinically stable, who was started on maintenance therapy with

75 mg colistimethate sodium delivered by inhalation twice daily by an

electronic vibrating plate nebulizer. The patient started having

increased respiratory symptoms within hours of the first dose. Three

days after initiating treatment, she required urgent hospital admission

with expectoration of large quantities of thin, pink secretions. She

rapidly developed progressive respiratory failure requiring mechanical

ventilation with bilateral ground glass appearance on chest x-ray. A

clinical diagnosis of acute respiratory distress syndrome (ARDS) was

made. Bronchoscopy on admission and 8 days later identified only usual

CF pathogens. The patient died 18 days later from multi-organ failure.

The FDA was informed by a MedWatch submission.


Colistimethate is a prodrug that must be hydrolyzed to the bioactive

form, colistin. The active form, colistin, unfortunately is toxic to

tissues including the airway. The most commonly prescribed form of the

prodrug, colistimethate, is Coly-Mycin. Typically colistimethate is

mixed with sterile water to form a solution prior to nebulization. When

colistimethate is mixed with water, hydrolysis of the prodrug to its

active form, colistin, begins. (Attachment B) Therefore, premixing and

storing colistimethate results in increasing concentrations of the more

active and toxic product, colistin, and adds a variable that may affect

the therapeutic window of the drug and undermine patient safety. This is

illustrated by the fact that the major active ingredient in colistin,

polymyxin E1, was abandoned as a potential pharmaceutical agent after

inhalation toxicity studies showed massive inflammation in both rodents

and dogs at low doses. (Attachment C). Furthermore, the hydrolysis of

colistimethate is complex and as many as 32 products are formed and any

one of these may have toxic effects on the airway.


It is the recommendation of the CF Foundation that patients not use

premixed vials of colistimethate until the FDA investigation is complete

and the safety profile is established. We understand that this may be

an inconvenience for patients using this formulation, but patient safety

is our primary concern. To be clear, we are not advising against the

use of Coly-Mycin when premixed immediately prior to nebulization.


We also ask that, if additional adverse events of compounded

colistimethate into premixed unit dose vials have occurred, you alert us

and submit a MedWatch form by visiting

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/medwatch/how.htm.">http://www.fda.gov/medwatch/how.htm.</a>

Jem
06-11-2007, 06:38 PM
<b>I received this...not sure of the validity but it is worth looking into if you are using pre-mixed vials of Colistin.</b>

Date: 6/11/2007 8:09 AM

Subject: URGENT: Colistin Alert from the Office of Drs. Preston Campbell and Bruce Marshall

Attachments: Attachment A, Colistin MedWatch 053107.pdf; Attachment B, Antimicrobia Journal Stability of Colistin Apr 2003.pdf; Attachment C, Poster 8 Day
Inhalation Toxicology of Polymyxin E1 in Colistin June 2001.pdf


TO: All Cystic Fibrosis Foundation Care Centers


FROM: Preston W. Campbell, III, M.D.

Executive Vice President for Medical Affairs

and

Bruce C. Marshall, M.D., Vice President for

Clinical Affairs

and

Leslie Hazle, M.S., C.P.N., R.N., Director of

Patient Resources


RE: Colistin Alert


We wanted to let you know that the Food and Drug Administration (FDA) is

investigating a recent patient death as possibly being related to

inhaled colistin that was supplied by a compounding pharmacy in premixed

unit dose vials. The purpose of this memo is to inform the prescribing

community of this unfortunate death (Attachment A) and give you

additional details regarding the hydrolysis of the prodrug

colistimethate to more toxic compounds when stored in solution. Our

recommendation is that patients not use premixed unit dose vials of

Colistimethate until the FDA investigation is complete and the safety of

this product is established.


The patient was a 29-year-old woman with cystic fibrosis (CF) with

chronic airway Pseudomonas aeruginosa infection with moderate lung

disease, clinically stable, who was started on maintenance therapy with

75 mg colistimethate sodium delivered by inhalation twice daily by an

electronic vibrating plate nebulizer. The patient started having

increased respiratory symptoms within hours of the first dose. Three

days after initiating treatment, she required urgent hospital admission

with expectoration of large quantities of thin, pink secretions. She

rapidly developed progressive respiratory failure requiring mechanical

ventilation with bilateral ground glass appearance on chest x-ray. A

clinical diagnosis of acute respiratory distress syndrome (ARDS) was

made. Bronchoscopy on admission and 8 days later identified only usual

CF pathogens. The patient died 18 days later from multi-organ failure.

The FDA was informed by a MedWatch submission.


Colistimethate is a prodrug that must be hydrolyzed to the bioactive

form, colistin. The active form, colistin, unfortunately is toxic to

tissues including the airway. The most commonly prescribed form of the

prodrug, colistimethate, is Coly-Mycin. Typically colistimethate is

mixed with sterile water to form a solution prior to nebulization. When

colistimethate is mixed with water, hydrolysis of the prodrug to its

active form, colistin, begins. (Attachment B) Therefore, premixing and

storing colistimethate results in increasing concentrations of the more

active and toxic product, colistin, and adds a variable that may affect

the therapeutic window of the drug and undermine patient safety. This is

illustrated by the fact that the major active ingredient in colistin,

polymyxin E1, was abandoned as a potential pharmaceutical agent after

inhalation toxicity studies showed massive inflammation in both rodents

and dogs at low doses. (Attachment C). Furthermore, the hydrolysis of

colistimethate is complex and as many as 32 products are formed and any

one of these may have toxic effects on the airway.


It is the recommendation of the CF Foundation that patients not use

premixed vials of colistimethate until the FDA investigation is complete

and the safety profile is established. We understand that this may be

an inconvenience for patients using this formulation, but patient safety

is our primary concern. To be clear, we are not advising against the

use of Coly-Mycin when premixed immediately prior to nebulization.


We also ask that, if additional adverse events of compounded

colistimethate into premixed unit dose vials have occurred, you alert us

and submit a MedWatch form by visiting

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/medwatch/how.htm.">http://www.fda.gov/medwatch/how.htm.</a>

Jem
06-11-2007, 06:38 PM
<b>I received this...not sure of the validity but it is worth looking into if you are using pre-mixed vials of Colistin.</b>

Date: 6/11/2007 8:09 AM

Subject: URGENT: Colistin Alert from the Office of Drs. Preston Campbell and Bruce Marshall

Attachments: Attachment A, Colistin MedWatch 053107.pdf; Attachment B, Antimicrobia Journal Stability of Colistin Apr 2003.pdf; Attachment C, Poster 8 Day
Inhalation Toxicology of Polymyxin E1 in Colistin June 2001.pdf


TO: All Cystic Fibrosis Foundation Care Centers


FROM: Preston W. Campbell, III, M.D.

Executive Vice President for Medical Affairs

and

Bruce C. Marshall, M.D., Vice President for

Clinical Affairs

and

Leslie Hazle, M.S., C.P.N., R.N., Director of

Patient Resources


RE: Colistin Alert


We wanted to let you know that the Food and Drug Administration (FDA) is

investigating a recent patient death as possibly being related to

inhaled colistin that was supplied by a compounding pharmacy in premixed

unit dose vials. The purpose of this memo is to inform the prescribing

community of this unfortunate death (Attachment A) and give you

additional details regarding the hydrolysis of the prodrug

colistimethate to more toxic compounds when stored in solution. Our

recommendation is that patients not use premixed unit dose vials of

Colistimethate until the FDA investigation is complete and the safety of

this product is established.


The patient was a 29-year-old woman with cystic fibrosis (CF) with

chronic airway Pseudomonas aeruginosa infection with moderate lung

disease, clinically stable, who was started on maintenance therapy with

75 mg colistimethate sodium delivered by inhalation twice daily by an

electronic vibrating plate nebulizer. The patient started having

increased respiratory symptoms within hours of the first dose. Three

days after initiating treatment, she required urgent hospital admission

with expectoration of large quantities of thin, pink secretions. She

rapidly developed progressive respiratory failure requiring mechanical

ventilation with bilateral ground glass appearance on chest x-ray. A

clinical diagnosis of acute respiratory distress syndrome (ARDS) was

made. Bronchoscopy on admission and 8 days later identified only usual

CF pathogens. The patient died 18 days later from multi-organ failure.

The FDA was informed by a MedWatch submission.


Colistimethate is a prodrug that must be hydrolyzed to the bioactive

form, colistin. The active form, colistin, unfortunately is toxic to

tissues including the airway. The most commonly prescribed form of the

prodrug, colistimethate, is Coly-Mycin. Typically colistimethate is

mixed with sterile water to form a solution prior to nebulization. When

colistimethate is mixed with water, hydrolysis of the prodrug to its

active form, colistin, begins. (Attachment B) Therefore, premixing and

storing colistimethate results in increasing concentrations of the more

active and toxic product, colistin, and adds a variable that may affect

the therapeutic window of the drug and undermine patient safety. This is

illustrated by the fact that the major active ingredient in colistin,

polymyxin E1, was abandoned as a potential pharmaceutical agent after

inhalation toxicity studies showed massive inflammation in both rodents

and dogs at low doses. (Attachment C). Furthermore, the hydrolysis of

colistimethate is complex and as many as 32 products are formed and any

one of these may have toxic effects on the airway.


It is the recommendation of the CF Foundation that patients not use

premixed vials of colistimethate until the FDA investigation is complete

and the safety profile is established. We understand that this may be

an inconvenience for patients using this formulation, but patient safety

is our primary concern. To be clear, we are not advising against the

use of Coly-Mycin when premixed immediately prior to nebulization.


We also ask that, if additional adverse events of compounded

colistimethate into premixed unit dose vials have occurred, you alert us

and submit a MedWatch form by visiting

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/medwatch/how.htm.">http://www.fda.gov/medwatch/how.htm.</a>

Jem
06-11-2007, 06:38 PM
<b>I received this...not sure of the validity but it is worth looking into if you are using pre-mixed vials of Colistin.</b>

Date: 6/11/2007 8:09 AM

Subject: URGENT: Colistin Alert from the Office of Drs. Preston Campbell and Bruce Marshall

Attachments: Attachment A, Colistin MedWatch 053107.pdf; Attachment B, Antimicrobia Journal Stability of Colistin Apr 2003.pdf; Attachment C, Poster 8 Day
Inhalation Toxicology of Polymyxin E1 in Colistin June 2001.pdf


TO: All Cystic Fibrosis Foundation Care Centers


FROM: Preston W. Campbell, III, M.D.

Executive Vice President for Medical Affairs

and

Bruce C. Marshall, M.D., Vice President for

Clinical Affairs

and

Leslie Hazle, M.S., C.P.N., R.N., Director of

Patient Resources


RE: Colistin Alert


We wanted to let you know that the Food and Drug Administration (FDA) is

investigating a recent patient death as possibly being related to

inhaled colistin that was supplied by a compounding pharmacy in premixed

unit dose vials. The purpose of this memo is to inform the prescribing

community of this unfortunate death (Attachment A) and give you

additional details regarding the hydrolysis of the prodrug

colistimethate to more toxic compounds when stored in solution. Our

recommendation is that patients not use premixed unit dose vials of

Colistimethate until the FDA investigation is complete and the safety of

this product is established.


The patient was a 29-year-old woman with cystic fibrosis (CF) with

chronic airway Pseudomonas aeruginosa infection with moderate lung

disease, clinically stable, who was started on maintenance therapy with

75 mg colistimethate sodium delivered by inhalation twice daily by an

electronic vibrating plate nebulizer. The patient started having

increased respiratory symptoms within hours of the first dose. Three

days after initiating treatment, she required urgent hospital admission

with expectoration of large quantities of thin, pink secretions. She

rapidly developed progressive respiratory failure requiring mechanical

ventilation with bilateral ground glass appearance on chest x-ray. A

clinical diagnosis of acute respiratory distress syndrome (ARDS) was

made. Bronchoscopy on admission and 8 days later identified only usual

CF pathogens. The patient died 18 days later from multi-organ failure.

The FDA was informed by a MedWatch submission.


Colistimethate is a prodrug that must be hydrolyzed to the bioactive

form, colistin. The active form, colistin, unfortunately is toxic to

tissues including the airway. The most commonly prescribed form of the

prodrug, colistimethate, is Coly-Mycin. Typically colistimethate is

mixed with sterile water to form a solution prior to nebulization. When

colistimethate is mixed with water, hydrolysis of the prodrug to its

active form, colistin, begins. (Attachment B) Therefore, premixing and

storing colistimethate results in increasing concentrations of the more

active and toxic product, colistin, and adds a variable that may affect

the therapeutic window of the drug and undermine patient safety. This is

illustrated by the fact that the major active ingredient in colistin,

polymyxin E1, was abandoned as a potential pharmaceutical agent after

inhalation toxicity studies showed massive inflammation in both rodents

and dogs at low doses. (Attachment C). Furthermore, the hydrolysis of

colistimethate is complex and as many as 32 products are formed and any

one of these may have toxic effects on the airway.


It is the recommendation of the CF Foundation that patients not use

premixed vials of colistimethate until the FDA investigation is complete

and the safety profile is established. We understand that this may be

an inconvenience for patients using this formulation, but patient safety

is our primary concern. To be clear, we are not advising against the

use of Coly-Mycin when premixed immediately prior to nebulization.


We also ask that, if additional adverse events of compounded

colistimethate into premixed unit dose vials have occurred, you alert us

and submit a MedWatch form by visiting

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/medwatch/how.htm.">http://www.fda.gov/medwatch/how.htm.</a>

Jem
06-11-2007, 06:38 PM
<b>I received this...not sure of the validity but it is worth looking into if you are using pre-mixed vials of Colistin.</b>

Date: 6/11/2007 8:09 AM

Subject: URGENT: Colistin Alert from the Office of Drs. Preston Campbell and Bruce Marshall

Attachments: Attachment A, Colistin MedWatch 053107.pdf; Attachment B, Antimicrobia Journal Stability of Colistin Apr 2003.pdf; Attachment C, Poster 8 Day
Inhalation Toxicology of Polymyxin E1 in Colistin June 2001.pdf


TO: All Cystic Fibrosis Foundation Care Centers


FROM: Preston W. Campbell, III, M.D.

Executive Vice President for Medical Affairs

and

Bruce C. Marshall, M.D., Vice President for

Clinical Affairs

and

Leslie Hazle, M.S., C.P.N., R.N., Director of

Patient Resources


RE: Colistin Alert


We wanted to let you know that the Food and Drug Administration (FDA) is

investigating a recent patient death as possibly being related to

inhaled colistin that was supplied by a compounding pharmacy in premixed

unit dose vials. The purpose of this memo is to inform the prescribing

community of this unfortunate death (Attachment A) and give you

additional details regarding the hydrolysis of the prodrug

colistimethate to more toxic compounds when stored in solution. Our

recommendation is that patients not use premixed unit dose vials of

Colistimethate until the FDA investigation is complete and the safety of

this product is established.


The patient was a 29-year-old woman with cystic fibrosis (CF) with

chronic airway Pseudomonas aeruginosa infection with moderate lung

disease, clinically stable, who was started on maintenance therapy with

75 mg colistimethate sodium delivered by inhalation twice daily by an

electronic vibrating plate nebulizer. The patient started having

increased respiratory symptoms within hours of the first dose. Three

days after initiating treatment, she required urgent hospital admission

with expectoration of large quantities of thin, pink secretions. She

rapidly developed progressive respiratory failure requiring mechanical

ventilation with bilateral ground glass appearance on chest x-ray. A

clinical diagnosis of acute respiratory distress syndrome (ARDS) was

made. Bronchoscopy on admission and 8 days later identified only usual

CF pathogens. The patient died 18 days later from multi-organ failure.

The FDA was informed by a MedWatch submission.


Colistimethate is a prodrug that must be hydrolyzed to the bioactive

form, colistin. The active form, colistin, unfortunately is toxic to

tissues including the airway. The most commonly prescribed form of the

prodrug, colistimethate, is Coly-Mycin. Typically colistimethate is

mixed with sterile water to form a solution prior to nebulization. When

colistimethate is mixed with water, hydrolysis of the prodrug to its

active form, colistin, begins. (Attachment B) Therefore, premixing and

storing colistimethate results in increasing concentrations of the more

active and toxic product, colistin, and adds a variable that may affect

the therapeutic window of the drug and undermine patient safety. This is

illustrated by the fact that the major active ingredient in colistin,

polymyxin E1, was abandoned as a potential pharmaceutical agent after

inhalation toxicity studies showed massive inflammation in both rodents

and dogs at low doses. (Attachment C). Furthermore, the hydrolysis of

colistimethate is complex and as many as 32 products are formed and any

one of these may have toxic effects on the airway.


It is the recommendation of the CF Foundation that patients not use

premixed vials of colistimethate until the FDA investigation is complete

and the safety profile is established. We understand that this may be

an inconvenience for patients using this formulation, but patient safety

is our primary concern. To be clear, we are not advising against the

use of Coly-Mycin when premixed immediately prior to nebulization.


We also ask that, if additional adverse events of compounded

colistimethate into premixed unit dose vials have occurred, you alert us

and submit a MedWatch form by visiting

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/medwatch/how.htm.">http://www.fda.gov/medwatch/how.htm.</a>

Jem
06-11-2007, 06:38 PM
<b>I received this...not sure of the validity but it is worth looking into if you are using pre-mixed vials of Colistin.</b>

Date: 6/11/2007 8:09 AM

Subject: URGENT: Colistin Alert from the Office of Drs. Preston Campbell and Bruce Marshall

Attachments: Attachment A, Colistin MedWatch 053107.pdf; Attachment B, Antimicrobia Journal Stability of Colistin Apr 2003.pdf; Attachment C, Poster 8 Day
Inhalation Toxicology of Polymyxin E1 in Colistin June 2001.pdf


TO: All Cystic Fibrosis Foundation Care Centers


FROM: Preston W. Campbell, III, M.D.

Executive Vice President for Medical Affairs

and

Bruce C. Marshall, M.D., Vice President for

Clinical Affairs

and

Leslie Hazle, M.S., C.P.N., R.N., Director of

Patient Resources


RE: Colistin Alert


We wanted to let you know that the Food and Drug Administration (FDA) is

investigating a recent patient death as possibly being related to

inhaled colistin that was supplied by a compounding pharmacy in premixed

unit dose vials. The purpose of this memo is to inform the prescribing

community of this unfortunate death (Attachment A) and give you

additional details regarding the hydrolysis of the prodrug

colistimethate to more toxic compounds when stored in solution. Our

recommendation is that patients not use premixed unit dose vials of

Colistimethate until the FDA investigation is complete and the safety of

this product is established.


The patient was a 29-year-old woman with cystic fibrosis (CF) with

chronic airway Pseudomonas aeruginosa infection with moderate lung

disease, clinically stable, who was started on maintenance therapy with

75 mg colistimethate sodium delivered by inhalation twice daily by an

electronic vibrating plate nebulizer. The patient started having

increased respiratory symptoms within hours of the first dose. Three

days after initiating treatment, she required urgent hospital admission

with expectoration of large quantities of thin, pink secretions. She

rapidly developed progressive respiratory failure requiring mechanical

ventilation with bilateral ground glass appearance on chest x-ray. A

clinical diagnosis of acute respiratory distress syndrome (ARDS) was

made. Bronchoscopy on admission and 8 days later identified only usual

CF pathogens. The patient died 18 days later from multi-organ failure.

The FDA was informed by a MedWatch submission.


Colistimethate is a prodrug that must be hydrolyzed to the bioactive

form, colistin. The active form, colistin, unfortunately is toxic to

tissues including the airway. The most commonly prescribed form of the

prodrug, colistimethate, is Coly-Mycin. Typically colistimethate is

mixed with sterile water to form a solution prior to nebulization. When

colistimethate is mixed with water, hydrolysis of the prodrug to its

active form, colistin, begins. (Attachment B) Therefore, premixing and

storing colistimethate results in increasing concentrations of the more

active and toxic product, colistin, and adds a variable that may affect

the therapeutic window of the drug and undermine patient safety. This is

illustrated by the fact that the major active ingredient in colistin,

polymyxin E1, was abandoned as a potential pharmaceutical agent after

inhalation toxicity studies showed massive inflammation in both rodents

and dogs at low doses. (Attachment C). Furthermore, the hydrolysis of

colistimethate is complex and as many as 32 products are formed and any

one of these may have toxic effects on the airway.


It is the recommendation of the CF Foundation that patients not use

premixed vials of colistimethate until the FDA investigation is complete

and the safety profile is established. We understand that this may be

an inconvenience for patients using this formulation, but patient safety

is our primary concern. To be clear, we are not advising against the

use of Coly-Mycin when premixed immediately prior to nebulization.


We also ask that, if additional adverse events of compounded

colistimethate into premixed unit dose vials have occurred, you alert us

and submit a MedWatch form by visiting

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/medwatch/how.htm.">http://www.fda.gov/medwatch/how.htm.</a>

Emily65Roses
06-11-2007, 07:33 PM
Oh crap, I'm sorry. I didn't see yours when I went ahead and posted mine. Thanks for posting it. <img src="i/expressions/face-icon-small-smile.gif" border="0">

Emily65Roses
06-11-2007, 07:33 PM
Oh crap, I'm sorry. I didn't see yours when I went ahead and posted mine. Thanks for posting it. <img src="i/expressions/face-icon-small-smile.gif" border="0">

Emily65Roses
06-11-2007, 07:33 PM
Oh crap, I'm sorry. I didn't see yours when I went ahead and posted mine. Thanks for posting it. <img src="i/expressions/face-icon-small-smile.gif" border="0">

Emily65Roses
06-11-2007, 07:33 PM
Oh crap, I'm sorry. I didn't see yours when I went ahead and posted mine. Thanks for posting it. <img src="i/expressions/face-icon-small-smile.gif" border="0">

Emily65Roses
06-11-2007, 07:33 PM
Oh crap, I'm sorry. I didn't see yours when I went ahead and posted mine. Thanks for posting it. <img src="i/expressions/face-icon-small-smile.gif" border="0">

Emily65Roses
06-11-2007, 07:33 PM
Oh crap, I'm sorry. I didn't see yours when I went ahead and posted mine. Thanks for posting it. <img src="i/expressions/face-icon-small-smile.gif" border="0">

JazzysMom
06-11-2007, 07:49 PM
DAMN.....thanks for the heads up! Scary stuff....

JazzysMom
06-11-2007, 07:49 PM
DAMN.....thanks for the heads up! Scary stuff....

JazzysMom
06-11-2007, 07:49 PM
DAMN.....thanks for the heads up! Scary stuff....

JazzysMom
06-11-2007, 07:49 PM
DAMN.....thanks for the heads up! Scary stuff....

JazzysMom
06-11-2007, 07:49 PM
DAMN.....thanks for the heads up! Scary stuff....

JazzysMom
06-11-2007, 07:49 PM
DAMN.....thanks for the heads up! Scary stuff....

lightNlife
06-11-2007, 08:14 PM
I can't find any information about this other than in this forum. Would someone please provide a link to the documents mentioned?

Thanks

lightNlife
06-11-2007, 08:14 PM
I can't find any information about this other than in this forum. Would someone please provide a link to the documents mentioned?

Thanks

lightNlife
06-11-2007, 08:14 PM
I can't find any information about this other than in this forum. Would someone please provide a link to the documents mentioned?

Thanks

lightNlife
06-11-2007, 08:14 PM
I can't find any information about this other than in this forum. Would someone please provide a link to the documents mentioned?

Thanks

lightNlife
06-11-2007, 08:14 PM
I can't find any information about this other than in this forum. Would someone please provide a link to the documents mentioned?

Thanks

lightNlife
06-11-2007, 08:14 PM
I can't find any information about this other than in this forum. Would someone please provide a link to the documents mentioned?

Thanks

MOME2RT
06-11-2007, 08:17 PM
Thanks for posting, I just got a call from Reeces' dotor about this! SCARY is right! We are going to start TOBI today until the mix it yourself colisitn comes in next month! Plus she thinks he may not be responding to the colistin after all. Since he has symptoms again as he did last month with a hospital stay.

She said see how he does on the TOBI. If not we may try HTS or Zithromax 3x a week.

MOME2RT
06-11-2007, 08:17 PM
Thanks for posting, I just got a call from Reeces' dotor about this! SCARY is right! We are going to start TOBI today until the mix it yourself colisitn comes in next month! Plus she thinks he may not be responding to the colistin after all. Since he has symptoms again as he did last month with a hospital stay.

She said see how he does on the TOBI. If not we may try HTS or Zithromax 3x a week.

MOME2RT
06-11-2007, 08:17 PM
Thanks for posting, I just got a call from Reeces' dotor about this! SCARY is right! We are going to start TOBI today until the mix it yourself colisitn comes in next month! Plus she thinks he may not be responding to the colistin after all. Since he has symptoms again as he did last month with a hospital stay.

She said see how he does on the TOBI. If not we may try HTS or Zithromax 3x a week.

MOME2RT
06-11-2007, 08:17 PM
Thanks for posting, I just got a call from Reeces' dotor about this! SCARY is right! We are going to start TOBI today until the mix it yourself colisitn comes in next month! Plus she thinks he may not be responding to the colistin after all. Since he has symptoms again as he did last month with a hospital stay.

She said see how he does on the TOBI. If not we may try HTS or Zithromax 3x a week.

MOME2RT
06-11-2007, 08:17 PM
Thanks for posting, I just got a call from Reeces' dotor about this! SCARY is right! We are going to start TOBI today until the mix it yourself colisitn comes in next month! Plus she thinks he may not be responding to the colistin after all. Since he has symptoms again as he did last month with a hospital stay.

She said see how he does on the TOBI. If not we may try HTS or Zithromax 3x a week.

MOME2RT
06-11-2007, 08:17 PM
Thanks for posting, I just got a call from Reeces' dotor about this! SCARY is right! We are going to start TOBI today until the mix it yourself colisitn comes in next month! Plus she thinks he may not be responding to the colistin after all. Since he has symptoms again as he did last month with a hospital stay.

She said see how he does on the TOBI. If not we may try HTS or Zithromax 3x a week.

dramamama
06-11-2007, 08:19 PM
I just called my pharmacy and they said it is a HUGE problem. The longer colistin is mixed, because it has certain protein??, it becomes toxic very quickly...within a few days.

He said they had a meeting on it this morning.

That is all I know.

dramamama
06-11-2007, 08:19 PM
I just called my pharmacy and they said it is a HUGE problem. The longer colistin is mixed, because it has certain protein??, it becomes toxic very quickly...within a few days.

He said they had a meeting on it this morning.

That is all I know.

dramamama
06-11-2007, 08:19 PM
I just called my pharmacy and they said it is a HUGE problem. The longer colistin is mixed, because it has certain protein??, it becomes toxic very quickly...within a few days.

He said they had a meeting on it this morning.

That is all I know.

dramamama
06-11-2007, 08:19 PM
I just called my pharmacy and they said it is a HUGE problem. The longer colistin is mixed, because it has certain protein??, it becomes toxic very quickly...within a few days.

He said they had a meeting on it this morning.

That is all I know.

dramamama
06-11-2007, 08:19 PM
I just called my pharmacy and they said it is a HUGE problem. The longer colistin is mixed, because it has certain protein??, it becomes toxic very quickly...within a few days.

He said they had a meeting on it this morning.

That is all I know.

dramamama
06-11-2007, 08:19 PM
I just called my pharmacy and they said it is a HUGE problem. The longer colistin is mixed, because it has certain protein??, it becomes toxic very quickly...within a few days.

He said they had a meeting on it this morning.

That is all I know.

Emily65Roses
06-11-2007, 08:19 PM
I can't find it either, Lauren. The only source I've seen other than this forum is the email I got from my CF doc. *shrug*

Emily65Roses
06-11-2007, 08:19 PM
I can't find it either, Lauren. The only source I've seen other than this forum is the email I got from my CF doc. *shrug*

Emily65Roses
06-11-2007, 08:19 PM
I can't find it either, Lauren. The only source I've seen other than this forum is the email I got from my CF doc. *shrug*

Emily65Roses
06-11-2007, 08:19 PM
I can't find it either, Lauren. The only source I've seen other than this forum is the email I got from my CF doc. *shrug*

Emily65Roses
06-11-2007, 08:19 PM
I can't find it either, Lauren. The only source I've seen other than this forum is the email I got from my CF doc. *shrug*

Emily65Roses
06-11-2007, 08:19 PM
I can't find it either, Lauren. The only source I've seen other than this forum is the email I got from my CF doc. *shrug*

julie
06-11-2007, 08:24 PM
Geez, this is some scarry S**t. Wooh, I always thought mixing it was such a pain, but now I'm grateful that I did. Thanks for the info...

julie
06-11-2007, 08:24 PM
Geez, this is some scarry S**t. Wooh, I always thought mixing it was such a pain, but now I'm grateful that I did. Thanks for the info...

julie
06-11-2007, 08:24 PM
Geez, this is some scarry S**t. Wooh, I always thought mixing it was such a pain, but now I'm grateful that I did. Thanks for the info...

julie
06-11-2007, 08:24 PM
Geez, this is some scarry S**t. Wooh, I always thought mixing it was such a pain, but now I'm grateful that I did. Thanks for the info...

julie
06-11-2007, 08:24 PM
Geez, this is some scarry S**t. Wooh, I always thought mixing it was such a pain, but now I'm grateful that I did. Thanks for the info...

julie
06-11-2007, 08:24 PM
Geez, this is some scarry S**t. Wooh, I always thought mixing it was such a pain, but now I'm grateful that I did. Thanks for the info...

Jem
06-11-2007, 08:29 PM
lightNlife, I received the email from [email protected]

Jem
06-11-2007, 08:29 PM
lightNlife, I received the email from [email protected]

Jem
06-11-2007, 08:29 PM
lightNlife, I received the email from [email protected]

Jem
06-11-2007, 08:29 PM
lightNlife, I received the email from [email protected]

Jem
06-11-2007, 08:29 PM
lightNlife, I received the email from [email protected]

Jem
06-11-2007, 08:29 PM
lightNlife, I received the email from [email protected]

jfarel
06-11-2007, 08:55 PM
Holy Crap! thanks for posting this. I take the pre-mixed stuff. I talked to my pharmacy today and they never mentioned. this leaves me in a quandry since I'm coming down with something and I'm not sure what else to take.

jfarel
06-11-2007, 08:55 PM
Holy Crap! thanks for posting this. I take the pre-mixed stuff. I talked to my pharmacy today and they never mentioned. this leaves me in a quandry since I'm coming down with something and I'm not sure what else to take.

jfarel
06-11-2007, 08:55 PM
Holy Crap! thanks for posting this. I take the pre-mixed stuff. I talked to my pharmacy today and they never mentioned. this leaves me in a quandry since I'm coming down with something and I'm not sure what else to take.

jfarel
06-11-2007, 08:55 PM
Holy Crap! thanks for posting this. I take the pre-mixed stuff. I talked to my pharmacy today and they never mentioned. this leaves me in a quandry since I'm coming down with something and I'm not sure what else to take.

jfarel
06-11-2007, 08:55 PM
Holy Crap! thanks for posting this. I take the pre-mixed stuff. I talked to my pharmacy today and they never mentioned. this leaves me in a quandry since I'm coming down with something and I'm not sure what else to take.

jfarel
06-11-2007, 08:55 PM
Holy Crap! thanks for posting this. I take the pre-mixed stuff. I talked to my pharmacy today and they never mentioned. this leaves me in a quandry since I'm coming down with something and I'm not sure what else to take.

jfarel
06-11-2007, 08:57 PM
The attachments say 2001 and 2003. Are we sure this is current?

jfarel
06-11-2007, 08:57 PM
The attachments say 2001 and 2003. Are we sure this is current?

jfarel
06-11-2007, 08:57 PM
The attachments say 2001 and 2003. Are we sure this is current?

jfarel
06-11-2007, 08:57 PM
The attachments say 2001 and 2003. Are we sure this is current?

jfarel
06-11-2007, 08:57 PM
The attachments say 2001 and 2003. Are we sure this is current?

jfarel
06-11-2007, 08:57 PM
The attachments say 2001 and 2003. Are we sure this is current?

Lilith
06-11-2007, 09:02 PM
Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!

Lilith
06-11-2007, 09:02 PM
Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!

Lilith
06-11-2007, 09:02 PM
Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!

Lilith
06-11-2007, 09:02 PM
Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!

Lilith
06-11-2007, 09:02 PM
Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!

Lilith
06-11-2007, 09:02 PM
Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!

jfarel
06-11-2007, 09:03 PM
Not sure what to think.

jfarel
06-11-2007, 09:03 PM
Not sure what to think.

jfarel
06-11-2007, 09:03 PM
Not sure what to think.

jfarel
06-11-2007, 09:03 PM
Not sure what to think.

jfarel
06-11-2007, 09:03 PM
Not sure what to think.

jfarel
06-11-2007, 09:03 PM
Not sure what to think.

NoExcuses
06-11-2007, 09:06 PM
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Lilith</b></i>

Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!</end quote></div>

this isn't the stuff that comes with it.

you get get pre-mixed or non-premixed stuff.

this has nothing to do with the eFlow

NoExcuses
06-11-2007, 09:06 PM
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Lilith</b></i>

Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!</end quote></div>

this isn't the stuff that comes with it.

you get get pre-mixed or non-premixed stuff.

this has nothing to do with the eFlow

NoExcuses
06-11-2007, 09:06 PM
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Lilith</b></i>

Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!</end quote></div>

this isn't the stuff that comes with it.

you get get pre-mixed or non-premixed stuff.

this has nothing to do with the eFlow

NoExcuses
06-11-2007, 09:06 PM
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Lilith</b></i>

Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!</end quote></div>

this isn't the stuff that comes with it.

you get get pre-mixed or non-premixed stuff.

this has nothing to do with the eFlow

NoExcuses
06-11-2007, 09:06 PM
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Lilith</b></i>

Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!</end quote>

this isn't the stuff that comes with it.

you get get pre-mixed or non-premixed stuff.

this has nothing to do with the eFlow

NoExcuses
06-11-2007, 09:06 PM
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Lilith</b></i>

Damn, I'm glad I mix my own. I'm also glad that I don't have the eFlow yet, if this is the stuff that comes with it. I'll stick to my ProNeb for a while yet, thank you very much! Whew!</end quote>

this isn't the stuff that comes with it.

you get get pre-mixed or non-premixed stuff.

this has nothing to do with the eFlow

NoExcuses
06-11-2007, 09:07 PM
i'm skeptical of the information... but we'll see....

NoExcuses
06-11-2007, 09:07 PM
i'm skeptical of the information... but we'll see....

NoExcuses
06-11-2007, 09:07 PM
i'm skeptical of the information... but we'll see....

NoExcuses
06-11-2007, 09:07 PM
i'm skeptical of the information... but we'll see....

NoExcuses
06-11-2007, 09:07 PM
i'm skeptical of the information... but we'll see....

NoExcuses
06-11-2007, 09:07 PM
i'm skeptical of the information... but we'll see....

jfarel
06-11-2007, 09:08 PM
Amy do you use pre-mixed in the eflow? that's what I use.

jfarel
06-11-2007, 09:08 PM
Amy do you use pre-mixed in the eflow? that's what I use.

jfarel
06-11-2007, 09:08 PM
Amy do you use pre-mixed in the eflow? that's what I use.

jfarel
06-11-2007, 09:08 PM
Amy do you use pre-mixed in the eflow? that's what I use.

jfarel
06-11-2007, 09:08 PM
Amy do you use pre-mixed in the eflow? that's what I use.

jfarel
06-11-2007, 09:08 PM
Amy do you use pre-mixed in the eflow? that's what I use.

Jem
06-11-2007, 09:10 PM
The best thing to do is hold off treatment tonight and call your cf doctor & colistin premixed supplier tomorrow morning to get the real deal. I hope it is a false alarm but better to play it safe.

Jem
06-11-2007, 09:10 PM
The best thing to do is hold off treatment tonight and call your cf doctor & colistin premixed supplier tomorrow morning to get the real deal. I hope it is a false alarm but better to play it safe.

Jem
06-11-2007, 09:10 PM
The best thing to do is hold off treatment tonight and call your cf doctor & colistin premixed supplier tomorrow morning to get the real deal. I hope it is a false alarm but better to play it safe.

Jem
06-11-2007, 09:10 PM
The best thing to do is hold off treatment tonight and call your cf doctor & colistin premixed supplier tomorrow morning to get the real deal. I hope it is a false alarm but better to play it safe.

Jem
06-11-2007, 09:10 PM
The best thing to do is hold off treatment tonight and call your cf doctor & colistin premixed supplier tomorrow morning to get the real deal. I hope it is a false alarm but better to play it safe.

Jem
06-11-2007, 09:10 PM
The best thing to do is hold off treatment tonight and call your cf doctor & colistin premixed supplier tomorrow morning to get the real deal. I hope it is a false alarm but better to play it safe.

NoExcuses
06-11-2007, 09:15 PM
Ya I use pre-mixed, but I was given the option to use non pre-mixed.

Same with the traditional neb. I had the option of mixing myself or getting pre-mixed.

I can't emphasize enough - this has nothing to do with the eFlow!!!

NoExcuses
06-11-2007, 09:15 PM
Ya I use pre-mixed, but I was given the option to use non pre-mixed.

Same with the traditional neb. I had the option of mixing myself or getting pre-mixed.

I can't emphasize enough - this has nothing to do with the eFlow!!!

NoExcuses
06-11-2007, 09:15 PM
Ya I use pre-mixed, but I was given the option to use non pre-mixed.

Same with the traditional neb. I had the option of mixing myself or getting pre-mixed.

I can't emphasize enough - this has nothing to do with the eFlow!!!

NoExcuses
06-11-2007, 09:15 PM
Ya I use pre-mixed, but I was given the option to use non pre-mixed.

Same with the traditional neb. I had the option of mixing myself or getting pre-mixed.

I can't emphasize enough - this has nothing to do with the eFlow!!!

NoExcuses
06-11-2007, 09:15 PM
Ya I use pre-mixed, but I was given the option to use non pre-mixed.

Same with the traditional neb. I had the option of mixing myself or getting pre-mixed.

I can't emphasize enough - this has nothing to do with the eFlow!!!

NoExcuses
06-11-2007, 09:15 PM
Ya I use pre-mixed, but I was given the option to use non pre-mixed.

Same with the traditional neb. I had the option of mixing myself or getting pre-mixed.

I can't emphasize enough - this has nothing to do with the eFlow!!!

lightNlife
06-11-2007, 10:07 PM
The most likely source of the problem was that she inhaled an old mixture. Premixed Colistin MUST be used within 7 days. That's why I prefer to mix my own--I know exactly when I mixed it, and what concentration I used.

Like Amy, I'm skeptical of the info. It looks like this was an isolated incident. Especially considering that I have no found any of the information about this anywhere other than here. There's nothing on SourceCF's site, nothing on Medwatch, or CFF or FDA. I also couldn't find any information about the doctors whose names appear in that email some of you received.

Again, this appears to be an isolated incident. Certainly it's a serious one, which is why it's purportedly being investigated. I'll make my final conclusions when I see some proof-positive documentation.

lightNlife
06-11-2007, 10:07 PM
The most likely source of the problem was that she inhaled an old mixture. Premixed Colistin MUST be used within 7 days. That's why I prefer to mix my own--I know exactly when I mixed it, and what concentration I used.

Like Amy, I'm skeptical of the info. It looks like this was an isolated incident. Especially considering that I have no found any of the information about this anywhere other than here. There's nothing on SourceCF's site, nothing on Medwatch, or CFF or FDA. I also couldn't find any information about the doctors whose names appear in that email some of you received.

Again, this appears to be an isolated incident. Certainly it's a serious one, which is why it's purportedly being investigated. I'll make my final conclusions when I see some proof-positive documentation.

lightNlife
06-11-2007, 10:07 PM
The most likely source of the problem was that she inhaled an old mixture. Premixed Colistin MUST be used within 7 days. That's why I prefer to mix my own--I know exactly when I mixed it, and what concentration I used.

Like Amy, I'm skeptical of the info. It looks like this was an isolated incident. Especially considering that I have no found any of the information about this anywhere other than here. There's nothing on SourceCF's site, nothing on Medwatch, or CFF or FDA. I also couldn't find any information about the doctors whose names appear in that email some of you received.

Again, this appears to be an isolated incident. Certainly it's a serious one, which is why it's purportedly being investigated. I'll make my final conclusions when I see some proof-positive documentation.

lightNlife
06-11-2007, 10:07 PM
The most likely source of the problem was that she inhaled an old mixture. Premixed Colistin MUST be used within 7 days. That's why I prefer to mix my own--I know exactly when I mixed it, and what concentration I used.

Like Amy, I'm skeptical of the info. It looks like this was an isolated incident. Especially considering that I have no found any of the information about this anywhere other than here. There's nothing on SourceCF's site, nothing on Medwatch, or CFF or FDA. I also couldn't find any information about the doctors whose names appear in that email some of you received.

Again, this appears to be an isolated incident. Certainly it's a serious one, which is why it's purportedly being investigated. I'll make my final conclusions when I see some proof-positive documentation.

lightNlife
06-11-2007, 10:07 PM
The most likely source of the problem was that she inhaled an old mixture. Premixed Colistin MUST be used within 7 days. That's why I prefer to mix my own--I know exactly when I mixed it, and what concentration I used.

Like Amy, I'm skeptical of the info. It looks like this was an isolated incident. Especially considering that I have no found any of the information about this anywhere other than here. There's nothing on SourceCF's site, nothing on Medwatch, or CFF or FDA. I also couldn't find any information about the doctors whose names appear in that email some of you received.

Again, this appears to be an isolated incident. Certainly it's a serious one, which is why it's purportedly being investigated. I'll make my final conclusions when I see some proof-positive documentation.

lightNlife
06-11-2007, 10:07 PM
The most likely source of the problem was that she inhaled an old mixture. Premixed Colistin MUST be used within 7 days. That's why I prefer to mix my own--I know exactly when I mixed it, and what concentration I used.

Like Amy, I'm skeptical of the info. It looks like this was an isolated incident. Especially considering that I have no found any of the information about this anywhere other than here. There's nothing on SourceCF's site, nothing on Medwatch, or CFF or FDA. I also couldn't find any information about the doctors whose names appear in that email some of you received.

Again, this appears to be an isolated incident. Certainly it's a serious one, which is why it's purportedly being investigated. I'll make my final conclusions when I see some proof-positive documentation.

jfarel
06-11-2007, 10:25 PM
When I get pre-mixed I get at least a two week supply from the pharmaceutical company. Are you sure its seven days? I think they've even sent a month supply before. I've used it well past seven days and never had a problem.

jfarel
06-11-2007, 10:25 PM
When I get pre-mixed I get at least a two week supply from the pharmaceutical company. Are you sure its seven days? I think they've even sent a month supply before. I've used it well past seven days and never had a problem.

jfarel
06-11-2007, 10:25 PM
When I get pre-mixed I get at least a two week supply from the pharmaceutical company. Are you sure its seven days? I think they've even sent a month supply before. I've used it well past seven days and never had a problem.

jfarel
06-11-2007, 10:25 PM
When I get pre-mixed I get at least a two week supply from the pharmaceutical company. Are you sure its seven days? I think they've even sent a month supply before. I've used it well past seven days and never had a problem.

jfarel
06-11-2007, 10:25 PM
When I get pre-mixed I get at least a two week supply from the pharmaceutical company. Are you sure its seven days? I think they've even sent a month supply before. I've used it well past seven days and never had a problem.

jfarel
06-11-2007, 10:25 PM
When I get pre-mixed I get at least a two week supply from the pharmaceutical company. Are you sure its seven days? I think they've even sent a month supply before. I've used it well past seven days and never had a problem.

lightNlife
06-11-2007, 10:46 PM
My mistake, the reconstituted sol'n should be used w/in 7 days.

I've found a really good study of the difference b/w colistin and colymycin, including the problems with it. I'll be updating my blog w/in the next few days.

One of the most important pieces of info I found, for those of us who mix our own, is that we need to be VERY careful not to let it get foamy. The foam is the result of impurities in the solution, and can interfere with nebbing it effectively.

lightNlife
06-11-2007, 10:46 PM
My mistake, the reconstituted sol'n should be used w/in 7 days.

I've found a really good study of the difference b/w colistin and colymycin, including the problems with it. I'll be updating my blog w/in the next few days.

One of the most important pieces of info I found, for those of us who mix our own, is that we need to be VERY careful not to let it get foamy. The foam is the result of impurities in the solution, and can interfere with nebbing it effectively.

lightNlife
06-11-2007, 10:46 PM
My mistake, the reconstituted sol'n should be used w/in 7 days.

I've found a really good study of the difference b/w colistin and colymycin, including the problems with it. I'll be updating my blog w/in the next few days.

One of the most important pieces of info I found, for those of us who mix our own, is that we need to be VERY careful not to let it get foamy. The foam is the result of impurities in the solution, and can interfere with nebbing it effectively.

lightNlife
06-11-2007, 10:46 PM
My mistake, the reconstituted sol'n should be used w/in 7 days.

I've found a really good study of the difference b/w colistin and colymycin, including the problems with it. I'll be updating my blog w/in the next few days.

One of the most important pieces of info I found, for those of us who mix our own, is that we need to be VERY careful not to let it get foamy. The foam is the result of impurities in the solution, and can interfere with nebbing it effectively.

lightNlife
06-11-2007, 10:46 PM
My mistake, the reconstituted sol'n should be used w/in 7 days.

I've found a really good study of the difference b/w colistin and colymycin, including the problems with it. I'll be updating my blog w/in the next few days.

One of the most important pieces of info I found, for those of us who mix our own, is that we need to be VERY careful not to let it get foamy. The foam is the result of impurities in the solution, and can interfere with nebbing it effectively.

lightNlife
06-11-2007, 10:46 PM
My mistake, the reconstituted sol'n should be used w/in 7 days.

I've found a really good study of the difference b/w colistin and colymycin, including the problems with it. I'll be updating my blog w/in the next few days.

One of the most important pieces of info I found, for those of us who mix our own, is that we need to be VERY careful not to let it get foamy. The foam is the result of impurities in the solution, and can interfere with nebbing it effectively.

MOME2RT
06-11-2007, 11:05 PM
Reece uses his after 7 days as well. They send us premixed for a month!

About the foam issue, when he is DONE with the colistin, I open it up to clean, there is a foam...BUT again this is when it is finished.

MOME2RT
06-11-2007, 11:05 PM
Reece uses his after 7 days as well. They send us premixed for a month!

About the foam issue, when he is DONE with the colistin, I open it up to clean, there is a foam...BUT again this is when it is finished.

MOME2RT
06-11-2007, 11:05 PM
Reece uses his after 7 days as well. They send us premixed for a month!

About the foam issue, when he is DONE with the colistin, I open it up to clean, there is a foam...BUT again this is when it is finished.

MOME2RT
06-11-2007, 11:05 PM
Reece uses his after 7 days as well. They send us premixed for a month!

About the foam issue, when he is DONE with the colistin, I open it up to clean, there is a foam...BUT again this is when it is finished.

MOME2RT
06-11-2007, 11:05 PM
Reece uses his after 7 days as well. They send us premixed for a month!

About the foam issue, when he is DONE with the colistin, I open it up to clean, there is a foam...BUT again this is when it is finished.

MOME2RT
06-11-2007, 11:05 PM
Reece uses his after 7 days as well. They send us premixed for a month!

About the foam issue, when he is DONE with the colistin, I open it up to clean, there is a foam...BUT again this is when it is finished.

respman
06-12-2007, 03:39 PM
It is very important to make sure your Colistin is refridgerated at all times. The hydrolysis of the prodrug into the more toxic colistin is significantly slowed by refridgeration. I run a compounding pharmacy and we never make premixed colistimethate until the day it goes out and it goes out on ice. We have never had a problem but we are suspending our premixed colistin and substituting self mix vials until the FDA investigation is completed.

I think the incident in question was a combination of a few different factors but better to play it safe. Conveinence is nice but only if it is safe.

Jim D BS, RRT

respman
06-12-2007, 03:39 PM
It is very important to make sure your Colistin is refridgerated at all times. The hydrolysis of the prodrug into the more toxic colistin is significantly slowed by refridgeration. I run a compounding pharmacy and we never make premixed colistimethate until the day it goes out and it goes out on ice. We have never had a problem but we are suspending our premixed colistin and substituting self mix vials until the FDA investigation is completed.

I think the incident in question was a combination of a few different factors but better to play it safe. Conveinence is nice but only if it is safe.

Jim D BS, RRT

respman
06-12-2007, 03:39 PM
It is very important to make sure your Colistin is refridgerated at all times. The hydrolysis of the prodrug into the more toxic colistin is significantly slowed by refridgeration. I run a compounding pharmacy and we never make premixed colistimethate until the day it goes out and it goes out on ice. We have never had a problem but we are suspending our premixed colistin and substituting self mix vials until the FDA investigation is completed.

I think the incident in question was a combination of a few different factors but better to play it safe. Conveinence is nice but only if it is safe.

Jim D BS, RRT

respman
06-12-2007, 03:39 PM
It is very important to make sure your Colistin is refridgerated at all times. The hydrolysis of the prodrug into the more toxic colistin is significantly slowed by refridgeration. I run a compounding pharmacy and we never make premixed colistimethate until the day it goes out and it goes out on ice. We have never had a problem but we are suspending our premixed colistin and substituting self mix vials until the FDA investigation is completed.

I think the incident in question was a combination of a few different factors but better to play it safe. Conveinence is nice but only if it is safe.

Jim D BS, RRT

respman
06-12-2007, 03:39 PM
It is very important to make sure your Colistin is refridgerated at all times. The hydrolysis of the prodrug into the more toxic colistin is significantly slowed by refridgeration. I run a compounding pharmacy and we never make premixed colistimethate until the day it goes out and it goes out on ice. We have never had a problem but we are suspending our premixed colistin and substituting self mix vials until the FDA investigation is completed.

I think the incident in question was a combination of a few different factors but better to play it safe. Conveinence is nice but only if it is safe.

Jim D BS, RRT

respman
06-12-2007, 03:39 PM
It is very important to make sure your Colistin is refridgerated at all times. The hydrolysis of the prodrug into the more toxic colistin is significantly slowed by refridgeration. I run a compounding pharmacy and we never make premixed colistimethate until the day it goes out and it goes out on ice. We have never had a problem but we are suspending our premixed colistin and substituting self mix vials until the FDA investigation is completed.

I think the incident in question was a combination of a few different factors but better to play it safe. Conveinence is nice but only if it is safe.

Jim D BS, RRT

Jem
06-12-2007, 03:52 PM
<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/aboutCFFoundation/NewsEvents/index.cfm?ID=6768&TYPE=1670">CFF article on Colistin alert</a>


Foundation Issues A Safety Alert Regarding Premixed Colistin

June 12, 2007

The Food and Drug Administration (FDA) is investigating a recent patient death as possibly being related to inhaled colistin (also known as colistimethate or Coly-Mycin), which was premixed by a mail-order pharmacy. Colistin is an antibiotic that may be inhaled to treat infections of the lungs.

The Cystic Fibrosis Foundation recommends that patients not use colistin that has been premixed by a pharmacy until the FDA investigation is complete and the safety of this product is established.

We understand that this may be an inconvenience for patients using premixed colistin, but patient safety is our primary concern. To be clear, we are not advising against the use of colistin when premixed by the patient immediately prior to use.

Patients and their families should contact their CF care center for more information and with questions/concerns regarding this or any other treatment.

Jem
06-12-2007, 03:52 PM
<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/aboutCFFoundation/NewsEvents/index.cfm?ID=6768&TYPE=1670">CFF article on Colistin alert</a>


Foundation Issues A Safety Alert Regarding Premixed Colistin

June 12, 2007

The Food and Drug Administration (FDA) is investigating a recent patient death as possibly being related to inhaled colistin (also known as colistimethate or Coly-Mycin), which was premixed by a mail-order pharmacy. Colistin is an antibiotic that may be inhaled to treat infections of the lungs.

The Cystic Fibrosis Foundation recommends that patients not use colistin that has been premixed by a pharmacy until the FDA investigation is complete and the safety of this product is established.

We understand that this may be an inconvenience for patients using premixed colistin, but patient safety is our primary concern. To be clear, we are not advising against the use of colistin when premixed by the patient immediately prior to use.

Patients and their families should contact their CF care center for more information and with questions/concerns regarding this or any other treatment.

Jem
06-12-2007, 03:52 PM
<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/aboutCFFoundation/NewsEvents/index.cfm?ID=6768&TYPE=1670">CFF article on Colistin alert</a>


Foundation Issues A Safety Alert Regarding Premixed Colistin

June 12, 2007

The Food and Drug Administration (FDA) is investigating a recent patient death as possibly being related to inhaled colistin (also known as colistimethate or Coly-Mycin), which was premixed by a mail-order pharmacy. Colistin is an antibiotic that may be inhaled to treat infections of the lungs.

The Cystic Fibrosis Foundation recommends that patients not use colistin that has been premixed by a pharmacy until the FDA investigation is complete and the safety of this product is established.

We understand that this may be an inconvenience for patients using premixed colistin, but patient safety is our primary concern. To be clear, we are not advising against the use of colistin when premixed by the patient immediately prior to use.

Patients and their families should contact their CF care center for more information and with questions/concerns regarding this or any other treatment.

Jem
06-12-2007, 03:52 PM
<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/aboutCFFoundation/NewsEvents/index.cfm?ID=6768&TYPE=1670">CFF article on Colistin alert</a>


Foundation Issues A Safety Alert Regarding Premixed Colistin

June 12, 2007

The Food and Drug Administration (FDA) is investigating a recent patient death as possibly being related to inhaled colistin (also known as colistimethate or Coly-Mycin), which was premixed by a mail-order pharmacy. Colistin is an antibiotic that may be inhaled to treat infections of the lungs.

The Cystic Fibrosis Foundation recommends that patients not use colistin that has been premixed by a pharmacy until the FDA investigation is complete and the safety of this product is established.

We understand that this may be an inconvenience for patients using premixed colistin, but patient safety is our primary concern. To be clear, we are not advising against the use of colistin when premixed by the patient immediately prior to use.

Patients and their families should contact their CF care center for more information and with questions/concerns regarding this or any other treatment.

Jem
06-12-2007, 03:52 PM
<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/aboutCFFoundation/NewsEvents/index.cfm?ID=6768&TYPE=1670">CFF article on Colistin alert</a>


Foundation Issues A Safety Alert Regarding Premixed Colistin

June 12, 2007

The Food and Drug Administration (FDA) is investigating a recent patient death as possibly being related to inhaled colistin (also known as colistimethate or Coly-Mycin), which was premixed by a mail-order pharmacy. Colistin is an antibiotic that may be inhaled to treat infections of the lungs.

The Cystic Fibrosis Foundation recommends that patients not use colistin that has been premixed by a pharmacy until the FDA investigation is complete and the safety of this product is established.

We understand that this may be an inconvenience for patients using premixed colistin, but patient safety is our primary concern. To be clear, we are not advising against the use of colistin when premixed by the patient immediately prior to use.

Patients and their families should contact their CF care center for more information and with questions/concerns regarding this or any other treatment.

Jem
06-12-2007, 03:52 PM
<a target=_blank class=ftalternatingbarlinklarge href="http://www.cff.org/aboutCFFoundation/NewsEvents/index.cfm?ID=6768&TYPE=1670">CFF article on Colistin alert</a>


Foundation Issues A Safety Alert Regarding Premixed Colistin

June 12, 2007

The Food and Drug Administration (FDA) is investigating a recent patient death as possibly being related to inhaled colistin (also known as colistimethate or Coly-Mycin), which was premixed by a mail-order pharmacy. Colistin is an antibiotic that may be inhaled to treat infections of the lungs.

The Cystic Fibrosis Foundation recommends that patients not use colistin that has been premixed by a pharmacy until the FDA investigation is complete and the safety of this product is established.

We understand that this may be an inconvenience for patients using premixed colistin, but patient safety is our primary concern. To be clear, we are not advising against the use of colistin when premixed by the patient immediately prior to use.

Patients and their families should contact their CF care center for more information and with questions/concerns regarding this or any other treatment.

jfarel
06-12-2007, 04:29 PM
I was under the impression that it needed to be room temperature when added to the eflow nebuliser. I always refrigerate and take it out prior to putting it in the eflow. Bad idea?

jfarel
06-12-2007, 04:29 PM
I was under the impression that it needed to be room temperature when added to the eflow nebuliser. I always refrigerate and take it out prior to putting it in the eflow. Bad idea?

jfarel
06-12-2007, 04:29 PM
I was under the impression that it needed to be room temperature when added to the eflow nebuliser. I always refrigerate and take it out prior to putting it in the eflow. Bad idea?

jfarel
06-12-2007, 04:29 PM
I was under the impression that it needed to be room temperature when added to the eflow nebuliser. I always refrigerate and take it out prior to putting it in the eflow. Bad idea?

jfarel
06-12-2007, 04:29 PM
I was under the impression that it needed to be room temperature when added to the eflow nebuliser. I always refrigerate and take it out prior to putting it in the eflow. Bad idea?

jfarel
06-12-2007, 04:29 PM
I was under the impression that it needed to be room temperature when added to the eflow nebuliser. I always refrigerate and take it out prior to putting it in the eflow. Bad idea?

Emily65Roses
06-12-2007, 04:30 PM
I put it in my neb right after taking it out of the fridge. I don't know that that's the ONLY way or the RIGHT way, but it's the way I do it. *shrug*

Emily65Roses
06-12-2007, 04:30 PM
I put it in my neb right after taking it out of the fridge. I don't know that that's the ONLY way or the RIGHT way, but it's the way I do it. *shrug*

Emily65Roses
06-12-2007, 04:30 PM
I put it in my neb right after taking it out of the fridge. I don't know that that's the ONLY way or the RIGHT way, but it's the way I do it. *shrug*

Emily65Roses
06-12-2007, 04:30 PM
I put it in my neb right after taking it out of the fridge. I don't know that that's the ONLY way or the RIGHT way, but it's the way I do it. *shrug*

Emily65Roses
06-12-2007, 04:30 PM
I put it in my neb right after taking it out of the fridge. I don't know that that's the ONLY way or the RIGHT way, but it's the way I do it. *shrug*

Emily65Roses
06-12-2007, 04:30 PM
I put it in my neb right after taking it out of the fridge. I don't know that that's the ONLY way or the RIGHT way, but it's the way I do it. *shrug*

respman
06-14-2007, 12:23 PM
It has to stay refidgerated until use. It's okay to use cold. Warming to room tempurature right before you use it won't increase the hydrolysis significantly, but the longer it is out the worse it will be. It is always safer to use right from the fridge.

Jim D BS, RRT

respman
06-14-2007, 12:23 PM
It has to stay refidgerated until use. It's okay to use cold. Warming to room tempurature right before you use it won't increase the hydrolysis significantly, but the longer it is out the worse it will be. It is always safer to use right from the fridge.

Jim D BS, RRT

respman
06-14-2007, 12:23 PM
It has to stay refidgerated until use. It's okay to use cold. Warming to room tempurature right before you use it won't increase the hydrolysis significantly, but the longer it is out the worse it will be. It is always safer to use right from the fridge.

Jim D BS, RRT

respman
06-14-2007, 12:23 PM
It has to stay refidgerated until use. It's okay to use cold. Warming to room tempurature right before you use it won't increase the hydrolysis significantly, but the longer it is out the worse it will be. It is always safer to use right from the fridge.

Jim D BS, RRT

respman
06-14-2007, 12:23 PM
It has to stay refidgerated until use. It's okay to use cold. Warming to room tempurature right before you use it won't increase the hydrolysis significantly, but the longer it is out the worse it will be. It is always safer to use right from the fridge.

Jim D BS, RRT

respman
06-14-2007, 12:23 PM
It has to stay refidgerated until use. It's okay to use cold. Warming to room tempurature right before you use it won't increase the hydrolysis significantly, but the longer it is out the worse it will be. It is always safer to use right from the fridge.

Jim D BS, RRT

TwistedTanya
06-21-2007, 09:16 PM
I have been using the pre-mixed Colistin for the e-flow for at least 2 years maybe 3 and never had any problems with it. I receive a months supply that comes cold with ice packs and is kept in my refrigerator. I truely believe this case is due to something else or maybe a bad batch or something like that. Yet, my doctor wants to be cautious and have me mix it myself until we know more. Oh how I hate this process!!! I do wish I had been more informed at how dangerous it could be after mixed and not refrigerated for a long time. I just thought it wasn't as effective. Now at least I will be a little more careful with taking it. It still has been the best antibiotic I have aver taken and done wonders for me! I have been on it for at least 5 or 6 years inhaled. Been doing it non stop everyday for the last 3 years. I just hope that this gets solved really quick!
I also feel so bad for the girl that went through this and died. How awful! I wouldn't be surprised if it wasn't some mistake made by a doctor or hospital or nurse after all the screw ups I have been through. I probably would have died by now if I hadn't caught a number of mistakes that had been done. Always be careful!!!

TwistedTanya
06-21-2007, 09:16 PM
I have been using the pre-mixed Colistin for the e-flow for at least 2 years maybe 3 and never had any problems with it. I receive a months supply that comes cold with ice packs and is kept in my refrigerator. I truely believe this case is due to something else or maybe a bad batch or something like that. Yet, my doctor wants to be cautious and have me mix it myself until we know more. Oh how I hate this process!!! I do wish I had been more informed at how dangerous it could be after mixed and not refrigerated for a long time. I just thought it wasn't as effective. Now at least I will be a little more careful with taking it. It still has been the best antibiotic I have aver taken and done wonders for me! I have been on it for at least 5 or 6 years inhaled. Been doing it non stop everyday for the last 3 years. I just hope that this gets solved really quick!
I also feel so bad for the girl that went through this and died. How awful! I wouldn't be surprised if it wasn't some mistake made by a doctor or hospital or nurse after all the screw ups I have been through. I probably would have died by now if I hadn't caught a number of mistakes that had been done. Always be careful!!!

TwistedTanya
06-21-2007, 09:16 PM
I have been using the pre-mixed Colistin for the e-flow for at least 2 years maybe 3 and never had any problems with it. I receive a months supply that comes cold with ice packs and is kept in my refrigerator. I truely believe this case is due to something else or maybe a bad batch or something like that. Yet, my doctor wants to be cautious and have me mix it myself until we know more. Oh how I hate this process!!! I do wish I had been more informed at how dangerous it could be after mixed and not refrigerated for a long time. I just thought it wasn't as effective. Now at least I will be a little more careful with taking it. It still has been the best antibiotic I have aver taken and done wonders for me! I have been on it for at least 5 or 6 years inhaled. Been doing it non stop everyday for the last 3 years. I just hope that this gets solved really quick!
I also feel so bad for the girl that went through this and died. How awful! I wouldn't be surprised if it wasn't some mistake made by a doctor or hospital or nurse after all the screw ups I have been through. I probably would have died by now if I hadn't caught a number of mistakes that had been done. Always be careful!!!

TwistedTanya
06-21-2007, 09:16 PM
I have been using the pre-mixed Colistin for the e-flow for at least 2 years maybe 3 and never had any problems with it. I receive a months supply that comes cold with ice packs and is kept in my refrigerator. I truely believe this case is due to something else or maybe a bad batch or something like that. Yet, my doctor wants to be cautious and have me mix it myself until we know more. Oh how I hate this process!!! I do wish I had been more informed at how dangerous it could be after mixed and not refrigerated for a long time. I just thought it wasn't as effective. Now at least I will be a little more careful with taking it. It still has been the best antibiotic I have aver taken and done wonders for me! I have been on it for at least 5 or 6 years inhaled. Been doing it non stop everyday for the last 3 years. I just hope that this gets solved really quick!
I also feel so bad for the girl that went through this and died. How awful! I wouldn't be surprised if it wasn't some mistake made by a doctor or hospital or nurse after all the screw ups I have been through. I probably would have died by now if I hadn't caught a number of mistakes that had been done. Always be careful!!!

TwistedTanya
06-21-2007, 09:16 PM
I have been using the pre-mixed Colistin for the e-flow for at least 2 years maybe 3 and never had any problems with it. I receive a months supply that comes cold with ice packs and is kept in my refrigerator. I truely believe this case is due to something else or maybe a bad batch or something like that. Yet, my doctor wants to be cautious and have me mix it myself until we know more. Oh how I hate this process!!! I do wish I had been more informed at how dangerous it could be after mixed and not refrigerated for a long time. I just thought it wasn't as effective. Now at least I will be a little more careful with taking it. It still has been the best antibiotic I have aver taken and done wonders for me! I have been on it for at least 5 or 6 years inhaled. Been doing it non stop everyday for the last 3 years. I just hope that this gets solved really quick!
I also feel so bad for the girl that went through this and died. How awful! I wouldn't be surprised if it wasn't some mistake made by a doctor or hospital or nurse after all the screw ups I have been through. I probably would have died by now if I hadn't caught a number of mistakes that had been done. Always be careful!!!

TwistedTanya
06-21-2007, 09:16 PM
I have been using the pre-mixed Colistin for the e-flow for at least 2 years maybe 3 and never had any problems with it. I receive a months supply that comes cold with ice packs and is kept in my refrigerator. I truely believe this case is due to something else or maybe a bad batch or something like that. Yet, my doctor wants to be cautious and have me mix it myself until we know more. Oh how I hate this process!!! I do wish I had been more informed at how dangerous it could be after mixed and not refrigerated for a long time. I just thought it wasn't as effective. Now at least I will be a little more careful with taking it. It still has been the best antibiotic I have aver taken and done wonders for me! I have been on it for at least 5 or 6 years inhaled. Been doing it non stop everyday for the last 3 years. I just hope that this gets solved really quick!
I also feel so bad for the girl that went through this and died. How awful! I wouldn't be surprised if it wasn't some mistake made by a doctor or hospital or nurse after all the screw ups I have been through. I probably would have died by now if I hadn't caught a number of mistakes that had been done. Always be careful!!!

flyer
06-29-2007, 10:03 PM
FYI, recent updates from the FDA website:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/advisory/colistimethate.htm">Public Health Advisory: Colistimethate</a>

and additional info for professionals:
<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/InfoSheets/HCP/colistimethateHCP.htm">Information for HealthCare Professionals: Colistimethate</a>

Talk to your trusted physician if you have any questions.

flyer
06-29-2007, 10:03 PM
FYI, recent updates from the FDA website:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/advisory/colistimethate.htm">Public Health Advisory: Colistimethate</a>

and additional info for professionals:
<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/InfoSheets/HCP/colistimethateHCP.htm">Information for HealthCare Professionals: Colistimethate</a>

Talk to your trusted physician if you have any questions.

flyer
06-29-2007, 10:03 PM
FYI, recent updates from the FDA website:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/advisory/colistimethate.htm">Public Health Advisory: Colistimethate</a>

and additional info for professionals:
<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/InfoSheets/HCP/colistimethateHCP.htm">Information for HealthCare Professionals: Colistimethate</a>

Talk to your trusted physician if you have any questions.

flyer
06-29-2007, 10:03 PM
FYI, recent updates from the FDA website:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/advisory/colistimethate.htm">Public Health Advisory: Colistimethate</a>

and additional info for professionals:
<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/InfoSheets/HCP/colistimethateHCP.htm">Information for HealthCare Professionals: Colistimethate</a>

Talk to your trusted physician if you have any questions.

flyer
06-29-2007, 10:03 PM
FYI, recent updates from the FDA website:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/advisory/colistimethate.htm">Public Health Advisory: Colistimethate</a>

and additional info for professionals:
<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/InfoSheets/HCP/colistimethateHCP.htm">Information for HealthCare Professionals: Colistimethate</a>

Talk to your trusted physician if you have any questions.

flyer
06-29-2007, 10:03 PM
FYI, recent updates from the FDA website:

<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/advisory/colistimethate.htm">Public Health Advisory: Colistimethate</a>

and additional info for professionals:
<a target=_blank class=ftalternatingbarlinklarge href="http://www.fda.gov/cder/drug/InfoSheets/HCP/colistimethateHCP.htm">Information for HealthCare Professionals: Colistimethate</a>

Talk to your trusted physician if you have any questions.

blondelawyer
06-29-2007, 10:17 PM
Thanks for the update flyer.

blondelawyer
06-29-2007, 10:17 PM
Thanks for the update flyer.

blondelawyer
06-29-2007, 10:17 PM
Thanks for the update flyer.

blondelawyer
06-29-2007, 10:17 PM
Thanks for the update flyer.

blondelawyer
06-29-2007, 10:17 PM
Thanks for the update flyer.

blondelawyer
06-29-2007, 10:17 PM
Thanks for the update flyer.

schmunks
07-03-2007, 11:51 AM
Hello,

I have just stumbled across this post and when i read it i was quite shocked to hear what happened to that patient.

What shocks me the most is that it sounds EXACTLY like what happened to my brother! 12/12/06

He was in hospital for the millionth time but was the same as always, then they made a decision to give him colistin for the first time about 3 days before he went into intensive care.

Do you think it could be the same or is this a normal turn of events for cf patients?


sarah cf33

schmunks
07-03-2007, 11:51 AM
Hello,

I have just stumbled across this post and when i read it i was quite shocked to hear what happened to that patient.

What shocks me the most is that it sounds EXACTLY like what happened to my brother! 12/12/06

He was in hospital for the millionth time but was the same as always, then they made a decision to give him colistin for the first time about 3 days before he went into intensive care.

Do you think it could be the same or is this a normal turn of events for cf patients?


sarah cf33

schmunks
07-03-2007, 11:51 AM
Hello,

I have just stumbled across this post and when i read it i was quite shocked to hear what happened to that patient.

What shocks me the most is that it sounds EXACTLY like what happened to my brother! 12/12/06

He was in hospital for the millionth time but was the same as always, then they made a decision to give him colistin for the first time about 3 days before he went into intensive care.

Do you think it could be the same or is this a normal turn of events for cf patients?


sarah cf33

schmunks
07-03-2007, 11:51 AM
Hello,

I have just stumbled across this post and when i read it i was quite shocked to hear what happened to that patient.

What shocks me the most is that it sounds EXACTLY like what happened to my brother! 12/12/06

He was in hospital for the millionth time but was the same as always, then they made a decision to give him colistin for the first time about 3 days before he went into intensive care.

Do you think it could be the same or is this a normal turn of events for cf patients?


sarah cf33

schmunks
07-03-2007, 11:51 AM
Hello,

I have just stumbled across this post and when i read it i was quite shocked to hear what happened to that patient.

What shocks me the most is that it sounds EXACTLY like what happened to my brother! 12/12/06

He was in hospital for the millionth time but was the same as always, then they made a decision to give him colistin for the first time about 3 days before he went into intensive care.

Do you think it could be the same or is this a normal turn of events for cf patients?


sarah cf33

schmunks
07-03-2007, 11:51 AM
Hello,

I have just stumbled across this post and when i read it i was quite shocked to hear what happened to that patient.

What shocks me the most is that it sounds EXACTLY like what happened to my brother! 12/12/06

He was in hospital for the millionth time but was the same as always, then they made a decision to give him colistin for the first time about 3 days before he went into intensive care.

Do you think it could be the same or is this a normal turn of events for cf patients?


sarah cf33